According to Kumar and Clark (2009) thirty percent of patients don’t require any interventions as they are asymptomatic and quiet healthy. The method of treatment depends on the following factors.
· Stage of the disease – if it is early stage no treatment will be given but the patient will be followed up regularly. Treatment is started immediately in advanced disease.
· Age of the patient
· Other illnesses in the patient
· Toxicity to treatment
The treatment helps to improve symptoms. Aggressive treatment has promised to give an increased survival rate. Patients with following features of advanced diseases are indicated for treatment.
· Marrow failure
· Recurrent infections
· Massive Hepatosplenomegally
· Fever
· Night sweats
· Loss of weight
· Haemolysis
The treatment methods available in chronic lymphocytic leukaemia can be divided in two main categories. They are,
1. Supportive treatment
2. Specific treatment
Supportive Treatment
The following drugs/treatment methods are used.
· Steroids – for anaemia
· Splenectomy
· Chemotherapy and transfusion for thrombocytopenia
· Antibiotics for ongoing infections and also as prophylaxis because these people are more prone to get recurrent infections because they are immunosuppressed.
· Allopurinol for hyperuricaemia.
Specific Treatment
Following drugs are used.
· Chlorambucil
· Purine analogues
· Combination therapy with rituximab
· Allogenic stem cell transplantation
References: Kumar P and Clark M, 2009. Clinical Medicine. 7th ed.
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